Oscar Millet Selected Research

Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)

5/2024	Congenital erythropoietic porphyria.
6/2021	Identification of novel UROS mutations in a patient with congenital erythropoietic porphyria and efficient treatment by phlebotomy.
5/2021	Improving the Pharmacological Properties of Ciclopirox for Its Use in Congenital Erythropoietic Porphyria.
1/2021	Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome.
1/2018	Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria.
1/2017	Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition.
11/2014	Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria.
11/2013	Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria.
4/2011	Intracellular rescue of the uroporphyrinogen III synthase activity in enzymes carrying the hotspot mutation C73R.
1/2011	Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase: molecular basis of congenital erythropoietic porphyria.

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Oscar Millet Research Topics

Disease

11	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 05/2024 - 01/2009
6	COVID-19 03/2024 - 01/2020
6	Non-alcoholic Fatty Liver Disease 02/2023 - 01/2021
6	Fibrosis (Cirrhosis) 10/2022 - 01/2016
3	Infections 01/2022 - 12/2020
2	Rare Diseases (Rare Disease) 12/2022 - 01/2021
2	Acute Intermittent Porphyria (Porphyria, Acute) 11/2022 - 11/2018
2	Inflammation (Inflammations) 09/2022 - 01/2022
2	Liver Diseases (Liver Disease) 01/2022 - 01/2017
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 01/2017
2	Tyrosinemias (Tyrosinemia) 02/2021 - 01/2019
2	Hemolytic Anemia 01/2017 - 11/2013
1	Septic Shock (Toxic Shock Syndrome) 03/2024
1	Sepsis (Septicemia) 03/2024
1	Hypoxia (Hypoxemia) 03/2024
1	Fatty Liver 01/2023
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2022
1	Atherosclerosis 12/2022
1	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 11/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Severe Acute Respiratory Syndrome 01/2022
1	Disease Progression 12/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 07/2021
1	Anemia 06/2021
1	Insulin Resistance 01/2021
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2021
1	Starvation 01/2021
1	Neoplasms (Cancer) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Trimethylaminuria 10/2019
1	Ketosis 10/2019

Drug/Important Bio-Agent (IBA)

10	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA 05/2024 - 01/2009
9	EnzymesIBA 05/2024 - 01/2011
7	Heme (Haem)IBA 05/2024 - 01/2011
6	Biomarkers (Surrogate Marker)IBA 09/2022 - 01/2016
5	PorphyrinsIBA 01/2022 - 11/2013
4	Phospholipids (Phosphatides)FDA LinkGeneric 03/2024 - 01/2021
4	Lipoproteins (Lipoprotein)IBA 03/2024 - 01/2021
4	Proteins (Proteins, Gene)FDA Link 12/2022 - 05/2014
3	LipidsIBA 03/2024 - 07/2021
3	Choline (Choline Chloride)IBA 01/2022 - 01/2016
2	Bile Acids and Salts (Bile Acids)IBA 03/2024 - 01/2017
2	S-Adenosylmethionine (Ademetionine)IBA 02/2023 - 12/2022
2	CarbonIBA 12/2022 - 01/2020
2	Protons (Proton)IBA 09/2022 - 01/2022
2	Methionine AdenosyltransferaseIBA 01/2022 - 01/2021
2	Polysaccharides (Glycans)IBA 01/2022 - 12/2020
2	ApolipoproteinsIBA 01/2022 - 01/2021
2	Ciclopirox (Loprox)FDA LinkGeneric 05/2021 - 01/2018
2	acetoacetic acid (acetoacetate)IBA 02/2021 - 01/2016
2	Proteasome InhibitorsIBA 01/2017 - 11/2013
1	NeopterinIBA 03/2024
1	dihydroceramideIBA 03/2024
1	phosphatidylethanolamineIBA 03/2024
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 03/2024
1	Amino Acids FDA Link 03/2024
1	Biogenic Amines (Biogenic Amine)IBA 03/2024
1	Cholesterol Esters (Cholesteryl Esters)IBA 03/2024
1	HDL CholesterolIBA 03/2024
1	Phosphatidylcholines (Phosphatidylcholine)IBA 03/2024
1	Tryptophan (L-Tryptophan)FDA Link 03/2024
1	indoleIBA 03/2024
1	Aminolevulinic Acid (Levulan)FDA Link 03/2024
1	hippuric acidIBA 03/2024
1	AcidsIBA 03/2024
1	propionic acid (potassium propionate)IBA 03/2024
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 03/2024
1	Lactic Acid (Lactate)FDA LinkGeneric 03/2024
1	Pyruvic Acid (Pyruvate)IBA 03/2024
1	ProteomeIBA 02/2023
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2023
1	O-GlcNAc transferaseIBA 01/2023
1	ChemokinesIBA 12/2022
1	Acute Hepatic PorphyriaIBA 11/2022
1	PorphobilinogenIBA 11/2022
1	Phospholipases (Phospholipase)IBA 10/2022
1	very low density lipoprotein triglycerideIBA 10/2022
1	VaccinesIBA 01/2022
1	IsomerasesIBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2022
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2022
1	Methionine (L-Methionine)FDA Link 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Bovine Serum AlbuminIBA 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	Ferritins (Ferritin)IBA 06/2021
1	fumarylacetoacetateIBA 02/2021
1	succinylacetoneIBA 02/2021
1	HydrolasesIBA 02/2021
1	HDL LipoproteinsIBA 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	IronIBA 01/2021
1	LectinsIBA 12/2020
1	NitrogenIBA 01/2020
1	Urea (Carbamide)FDA LinkGeneric 01/2020
1	trimethylamineIBA 10/2019